Praziquantel is a pyrazinoquinoline compound originally developed for the treatment of schistosomiasis but has been found to have a wide spectrum of anthelminthic activity. Praziquantel is a racemate but the R (+) enantiomer is solely responsible for its antiparasitic activity. It is active against trematodes (all Schistosoma species pathogenic to man, Paragonimus westermani, and Clonorchis sinensis) and cestodes (Taenia saginata, Taenia solium, Hymenolepis nana and Diphyllobothrium latum).Praziquantel is a broad-spectrum antihelmintic, effective against Schistosoma japonicum, Schistosoma mansoni and Schistosoma egypti, Schistosoma mansoni, Schistosoma haematobium, Schistosoma capsulatum, Cestodes and Cysticerci. It is the most effective anthelmintic for schistosomes, especially for tapeworms, and is the most productive of all schistosomiasis drugs.Praziquantel has a significant killing effect on adult schistosomes. The mechanism of killing, at the molecular level, is that praziquantel rapidly disrupts the Ca2+ balance in the body of the worm, which leads to excitation and muscle contracture, so that the parasitic schistosomes in the portal system cannot attach to the vessel walls and are carried by the blood stream to the liver (hepatic metastasis), where they are damaged; secondly, it causes damage to the syncytial cortex of the schistosome, which in addition to affecting the absorption, excretion and secretion functions of the worm, leads to disruption of glucose metabolism, enzyme systems, etc. In addition to the disruption of glucose metabolism and enzymatic systems, the antigenic determinants on the surface of the worm are exposed and recognized by the host's immune system, attracting a large number of inflammatory cells such as neutrophils, eosinophils and macrophages to gather around the worm and attack it.
mode of transportation
By Air
By Express
By Sea
suitable for >50
suitable for sampple order or <50
suitable for >300
Fast:3-7 days
Fast:3-10 days
Fast: 7-45 days
lower than the express cost
high shipping cost
lowest cost
Qingdao Qingmei Biotech Co., Ltd is a pharmaceutical company, which is to expand international business and strategic cooperation with Contract Manufacturing on Supplements(Hard Capsules, Softgels, Powders, Sachet), Active Ingredients for Human Health and Animal Health, Herbal Extracts, Food Additives, Feed Additives, Vitamins, Amino Acids, Minerals, Cosmetics raw materials, Pet Medicines, Disinfectant, Farming and Fishery Industry.
The company is located in the beautiful coastal city of Qingdao, near City Hall and the May Fourth Square, and also close to the port, so that it has convenient traffic conditions for trade. The company's business focuses on the development and promotion of the pharmaceutical chemicals, animal health, food additives, plant extracts, cosmetic raw materials, intermediates and other fine chemicals. Production in Qingmei is in accordance with GMP standards, and files are compiled and registered in regulated market to ensure smooth supply channels. Guided by the market development, Qingmei works hard to cover more customers.
Our products are approved by cGMP, CEP/COS, FDA, TGA, EUGMP, FAMI-QS and also Halal, Kosher etc.
Our products are widely sold to regions of Asia, Africa, Europe, Latin America, and long-term stable cooperative relations have been established with merchants from hundreds of countries and regions with our cooperation agencies in Turkey, South Africa, Indonesia, Russia, Brazil, Canada and the United States working stably. We are looking forward to making progress together with you!
1:Can I get some samples before bulk order?Most products provide free samples, but the shipping cost be paid by customers.2: What's your MOQ?For the high value product, our MOQ starts from 10g,100g and 1kg.3: Which kind of payment terms do you accept?PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C.4.How to place an order?You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.5:How about your delivery time?A: Generally, it will take 5 to 7 days after receiving your advance payment.6:How do you treat quality complaint?A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
For more information Praziquantel Api Manufacturers, please get in touch with us!