The diaphragm is the central sealing element in the valve. Only the diaphragm and valve body are in direct contact with the flowing medium. The design of the basic weir-style diaphragm valve seal presents a number of issues for process engineers working in the biotechnology and pharmaceutical industry. In typical configurations, a weir in the valve body rises in a fluid path and when the valve is closed, the diaphragm meets the weir to shut off the flow. While a simple technology intended to reduce turbulence and shear, weir-style valves present a number of issues, for example in upstream processing applications they can be difficult to install, prone to leaks, and increase the potential of product contamination.
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